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Article

Familial risk for major depression: differential white matter alterations in healthy and depressed participants.

Psychological medicine - 1 Aug 2023

Winter Alexandra, Thiel Katharina, Meinert Susanne, Lemke Hannah, Waltemate Lena, Breuer Fabian, Culemann Regina, Pfarr Julia-Katharina, Stein Frederike, Brosch Katharina, Meller Tina, Ringwald Kai Gustav, Thomas-Odenthal Florian, Jansen Andreas, Nenadić Igor, Krug Axel, Repple Jonathan, Opel Nils, Dohm Katharina, Leehr Elisabeth J, Grotegerd Dominik, Kugel Harald, Hahn Tim, Kircher Tilo, Dannlowski Udo

Abstract excerpt

BACKGROUND: Major depressive disorder (MDD) has been associated with alterations in brain white matter (WM) microstructure. However, diffusion tensor imaging studies in biological relatives have presented contradicting results on WM alterations and their potential as biomarkers for vulnerability or resilience. To shed more light on associations between WM microstructure and resilience to familial risk, analyses...

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PMID: 36052484
DOI: 10.1017/S003329172200188X
PMCID: PMC10476061

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