Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Trypanosoma brucei TIF2 and TRF Suppress VSG Switching Using Overlapping and Independent Mechanisms.

PloS one - 1 Jan 2016

Jehi Sanaa E, Nanavaty Vishal, Li Bibo

Abstract excerpt

Trypanosoma brucei causes debilitating human African trypanosomiasis and evades the host's immune response by regularly switching its major surface antigen, VSG, which is expressed exclusively from subtelomeric loci. We previously showed that two interacting telomere proteins, TbTRF and TbTIF2, are essential for cell proliferation and suppress VSG switching by inhibiting DNA recombination events involving the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigenic Variation
Share to Chromosomal Proteins, Non-Histone
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Protozoan

Share to Gene Conversion

Share to Proteasome Endopeptidase Complex

Share to Protozoan Proteins

Share to Trypanosoma brucei brucei

Source

Open in PubMed Open full text

Identifiers

PMID: 27258069
DOI: 10.1371/journal.pone.0156746
PMCID: PMC4892550

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Trypanosoma brucei TIF2 and TRF Suppress VSG Switching Using Overlapping and Independent Mechanisms.PMID 27258069Read ↗

Suppression of subtelomeric VSG switching by Trypanosoma brucei TRF requires its TTAGGG repeat-binding activity.Semantic proximity Read ↗

TelAP1 links telomere complexes with developmental expression site silencing in African trypanosomesSemantic proximity Read ↗

TbTRF suppresses the TERRA level and regulates the cell cycle-dependent TERRA foci number with a TERRA binding activity in its C-terminal Myb domainSemantic proximity Read ↗

TbISWI regulates multiple polymerase I (Pol I)-transcribed loci and is present at Pol II transcription boundaries in Trypanosoma brucei.Semantic proximity Read ↗

Telomere length affects the frequency and mechanism of antigenic variation in Trypanosoma brucei.Semantic proximity Read ↗

Trypanosoma brucei ATR Links DNA Damage Signaling during Antigenic Variation with Regulation of RNA Polymerase I-Transcribed Surface Antigens.Semantic proximity Read ↗

Telomere and Subtelomere R-loops and Antigenic Variation in Trypanosomes.Semantic proximity Read ↗

T rypanosoma brucei Orc 1 is essential for nuclear DNA replication and affects both VSG silencing and VSG switchingSemantic proximity Read ↗

African trypanosomes expressing multiple VSGs are rapidly eliminated by the host immune systemSemantic proximity Read ↗

Trypanosoma brucei RAP1 maintains telomere and subtelomere integrity by suppressing TERRA and telomeric RNA:DNA hybridsSemantic proximity Read ↗

A novel ISWI is involved in VSG expression site downregulation in African trypanosomes.Semantic proximity Read ↗

African trypanosomes: the genome and adaptations for immune evasionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.