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TelAP1 links telomere complexes with developmental expression site silencing in African trypanosomes

25 Jan 2018

Abstract excerpt

During its life cycle, Trypanosoma brucei shuttles between a mammalian host and the tsetse fly vector. In the mammalian host, immune evasion of T. brucei bloodstream form (BSF) cells relies on antigenic variation, which includes monoallelic expression and periodic switching of variant surface glycoprotein (VSG) genes. The active VSG is transcribed from only 1 of the 15 subtelomeric expression sites (ESs). During...

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PMID: 29385523
DOI: 10.1093/nar/gky028

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