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Article

Trypanosoma brucei ATR Links DNA Damage Signaling during Antigenic Variation with Regulation of RNA Polymerase I-Transcribed Surface Antigens.

Cell reports - 21 Jan 2020

Black Jennifer Ann, Crouch Kathryn, Lemgruber Leandro, Lapsley Craig, Dickens Nicholas, Tosi Luiz R O, Mottram Jeremy C, McCulloch Richard

Abstract excerpt

Trypanosoma brucei evades mammalian immunity by using recombination to switch its surface-expressed variant surface glycoprotein (VSG), while ensuring that only one of many subtelomeric multigene VSG expression sites are transcribed at a time. DNA repair activities have been implicated in the catalysis of VSG switching by recombination, not transcriptional control. How VSG switching is signaled to guide the...

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Identifiers

PMID: 31968257
DOI: 10.1016/j.celrep.2019.12.049
PMCID: PMC6988115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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