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Article

Telomere and Subtelomere R-loops and Antigenic Variation in Trypanosomes.

Journal of molecular biology - 10 Jul 2020

Saha Arpita, Nanavaty Vishal P, Li Bibo

Abstract excerpt

Trypanosoma brucei is a kinetoplastid parasite that causes African trypanosomiasis, which is fatal if left untreated. T. brucei regularly switches its major surface antigen, VSG, to evade the host immune responses. VSGs are exclusively expressed from subtelomeric expression sites (ESs) where VSG genes are flanked by upstream 70 bp repeats and downstream telomeric repeats. The telomere downstream of the active VSG...

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Identifiers

PMID: 31682833
DOI: 10.1016/j.jmb.2019.10.025
PMCID: PMC7195242

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