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T rypanosoma brucei Orc 1 is essential for nuclear DNA replication and affects both VSG silencing and VSG switching

10 Dec 2012

Abstract excerpt

Binding of the Origin Recognition Complex (ORC) to replication origins is essential for initiation of DNA replication, but ORC has non-essential functions outside of DNA replication, including in heterochromatic gene silencing and telomere maintenance. Trypanosoma brucei, a protozoan parasite that causes human African trypanosomiasis, uses antigenic variation as a major virulence mechanism to evade the host's...

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PMID: 23216794
DOI: 10.1111/mmi.12093

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