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Article

A novel ISWI is involved in VSG expression site downregulation in African trypanosomes.

The EMBO journal - 2 May 2007

Hughes Katie, Wand Matthew, Foulston Lucy, Young Rosanna, Harley Kate, Terry Stephen, Ersfeld Klaus, Rudenko Gloria

Abstract excerpt

African trypanosomes show monoallelic expression of one of about 20 telomeric variant surface glycoprotein (VSG) gene-expression sites (ESs) while multiplying in the mammalian bloodstream. We screened for genes involved in ES silencing using flow cytometry and RNA interference (RNAi). We show that a novel member of the ISWI family of SWI2/SNF2-related chromatin-remodelling proteins (TbISWI) is involved in ES...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17431399
DOI: 10.1038/sj.emboj.7601678
PMCID: PMC1864976

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A novel ISWI is involved in VSG expression site downregulation in African trypanosomes.PMID 17431399Read ↗

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