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Article

Suppression of subtelomeric VSG switching by Trypanosoma brucei TRF requires its TTAGGG repeat-binding activity.

Nucleic acids research - 10 Nov 2014

Jehi Sanaa E, Li Xiaohua, Sandhu Ranjodh, Ye Fei, Benmerzouga Imaan, Zhang Mingjie, Zhao Yanxiang, Li Bibo

Abstract excerpt

Trypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen, VSG, in the bloodstream of its mammalian host to evade the host immune response. VSGs are expressed exclusively from subtelomeric loci, and we have previously shown that telomere proteins TbT...

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Identifiers

PMID: 25313155
DOI: 10.1093/nar/gku942
PMCID: PMC4227783

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25313155-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Suppression of subtelomeric VSG switching by Trypanosoma brucei TRF requires its TTAGGG repeat-binding activity.PMID 25313155Read ↗

Trypanosoma brucei TIF2 and TRF Suppress VSG Switching Using Overlapping and Independent Mechanisms.Semantic proximity Read ↗

TbTRF suppresses the TERRA level and regulates the cell cycle-dependent TERRA foci number with a TERRA binding activity in its C-terminal Myb domainSemantic proximity Read ↗

The RRM-mediated RNA binding activity in T. brucei RAP1 is essential for VSG monoallelic expressionSemantic proximity Read ↗

Trypanosoma brucei RAP1 maintains telomere and subtelomere integrity by suppressing TERRA and telomeric RNA:DNA hybridsSemantic proximity Read ↗

Telomere and Subtelomere R-loops and Antigenic Variation in Trypanosomes.Semantic proximity Read ↗

DNA Double-Strand Breaks and Telomeres Play Important Roles in Trypanosoma brucei Antigenic VariationSemantic proximity Read ↗

Silencing subtelomeric VSGs by Trypanosoma brucei RAP1 at the insect stage involves chromatin structure changesSemantic proximity Read ↗

TelAP1 links telomere complexes with developmental expression site silencing in African trypanosomesSemantic proximity Read ↗

T rypanosoma brucei Orc 1 is essential for nuclear DNA replication and affects both VSG silencing and VSG switchingSemantic proximity Read ↗

Telomere length affects the frequency and mechanism of antigenic variation in Trypanosoma brucei.Semantic proximity Read ↗

The Structure of a Conserved Telomeric Region Associated with Variant Antigen Loci in the Blood Parasite Trypanosoma congolenseSemantic proximity Read ↗

TbISWI regulates multiple polymerase I (Pol I)-transcribed loci and is present at Pol II transcription boundaries in Trypanosoma brucei.Semantic proximity Read ↗

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