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Article

Telomere length affects the frequency and mechanism of antigenic variation in Trypanosoma brucei.

PLoS pathogens - 1 Jan 2012

Hovel-Miner Galadriel A, Boothroyd Catharine E, Mugnier Monica, Dreesen Oliver, Cross George A M, Papavasiliou F Nina

Abstract excerpt

Trypanosoma brucei is a master of antigenic variation and immune response evasion. Utilizing a genomic repertoire of more than 1000 Variant Surface Glycoprotein-encoding genes (VSGs), T. brucei can change its protein coat by "switching" from the expression of one VSG to another. Each active VSG is monoallelically expressed from only one of approximately 15 subtelomeric sites. Switching VSG expression occurs by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22952449
DOI: 10.1371/journal.ppat.1002900
PMCID: PMC3431348

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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