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Article

TbTRF suppresses the TERRA level and regulates the cell cycle-dependent TERRA foci number with a TERRA binding activity in its C-terminal Myb domain

29 Apr 2021

Abstract excerpt

Telomere repeat-containing RNA (TERRA) has been identified in multiple organisms including Trypanosoma brucei, a protozoan parasite that causes human African trypanosomiasis. T. brucei regularly switches its major surface antigen, VSG, to evade the host immune response. VSG is expressed exclusively from subtelomeric expression sites, and we have shown that telomere proteins play important roles in the regulation...

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Share to Cytomegalovirus and herpesvirus research
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PMID: 34048580
DOI: 10.1093/nar/gkab401

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TbTRF suppresses the TERRA level and regulates the cell cycle-dependent TERRA foci number with a TERRA binding activity in its C-terminal Myb domainPMID 34048580Read ↗

Suppression of subtelomeric VSG switching by Trypanosoma brucei TRF requires its TTAGGG repeat-binding activity.Semantic proximity Read ↗

Trypanosoma brucei RAP1 maintains telomere and subtelomere integrity by suppressing TERRA and telomeric RNA:DNA hybridsSemantic proximity Read ↗

Role of TERRA in the Regulation of Telomere LengthSemantic proximity Read ↗

CTCF driven TERRA transcription facilitates completion of telomere DNA replication.Semantic proximity Read ↗

The RRM-mediated RNA binding activity in T. brucei RAP1 is essential for VSG monoallelic expressionSemantic proximity Read ↗

TERRA transcripts localize at long telomeres to regulate telomerase access to chromosome endsSemantic proximity Read ↗

A practical qPCR approach to detect TERRA, the elusive telomeric repeat-containing RNASemantic proximity Read ↗

RTEL1 influences the abundance and localization of TERRA RNASemantic proximity Read ↗

In Vitro Characterization of the Physical Interactions between the Long Noncoding RNA TERRA and the Telomeric Proteins TRF1 and TRF2Semantic proximity Read ↗

RBMX involves in telomere stability maintenance by regulating TERRA expressionSemantic proximity Read ↗

BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage.Semantic proximity Read ↗

Functional characterization of the TERRA transcriptome at damaged telomeresSemantic proximity Read ↗

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