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Article

Chronology in lesion tolerance gives priority to genetic variability.

Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 2014

Naiman Karel, Philippin Gaëlle, Fuchs Robert P, Pagès Vincent

Abstract excerpt

The encounter of a replication fork with a blocking DNA lesion is a common event that cells need to address properly to preserve genome integrity. Cells possess two main strategies to tolerate unrepaired lesions: potentially mutagenic translesion synthesis (TLS) and nonmutagenic damage avoidance (DA). Little is known about the partitioning between these two strategies. Because genes involved in DA mechanisms...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 24706928
DOI: 10.1073/pnas.1321008111
PMCID: PMC3992691

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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