Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Stalled replication fork repair and misrepair during thymineless death in Escherichia coli.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jun 2010

Kuong Kawai J, Kuzminov Andrei

Abstract excerpt

Starvation for DNA precursor dTTP, known as 'thymineless death' (TLD), kills bacterial and eukaryotic cells alike. Despite numerous investigations, toxic mechanisms behind TLD remain unknown, although wrong nucleotide incorporation with subsequent excision dominates the explanations. We show that kinetics of TLD in Escherichia coli is not affected by mutations in DNA repair, ruling out excision after massive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Bacterial
Share to DNA Fragmentation
Share to DNA Helicases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Microbial Viability

Share to MutS DNA Mismatch-Binding Protein

Share to Rec A Recombinases

Share to SOS Response, Genetics

Share to Thymine

Source

Open in PubMed Open full text

Identifiers

PMID: 20465561
DOI: 10.1111/j.1365-2443.2010.01405.x
PMCID: PMC3965187

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Stalled replication fork repair and misrepair during thymineless death in Escherichia coli.PMID 20465561Read ↗

Thymine-starvation-induced chromosomal fragmentation is not required for thymineless death in Escherichia coli.Semantic proximity Read ↗

Disintegration of nascent replication bubbles during thymine starvation triggers RecA- and RecBCD-dependent replication origin destruction.Semantic proximity Read ↗

Thymine metabolism and thymineless death in prokaryotes and eukaryotes.Semantic proximity Read ↗

Chromosome demise in the wake of ligase-deficient replication.Semantic proximity Read ↗

RdgB acts to avoid chromosome fragmentation in Escherichia coli.Semantic proximity Read ↗

Resolving Toxic DNA repair intermediates in every E. coli replication cycle: critical roles for RecG, Uup and RadD.Semantic proximity Read ↗

A defect in homologous recombination leads to increased translesion synthesis in E. coli.Semantic proximity Read ↗

Defects in the central metabolism prevent thymineless death in Escherichia coli, while still allowing significant protein synthesis.Semantic proximity Read ↗

Chromosomal fragmentation in dUTPase-deficient mutants of Escherichia coli and its recombinational repair.Semantic proximity Read ↗

UV-induced DNA damage disrupts the coordination between replication initiation, elongation and completion.Semantic proximity Read ↗

Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.Semantic proximity Read ↗

RecQ promotes toxic recombination in cells lacking recombination intermediate-removal proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.