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Article

Functional fine-tuning between bacterial DNA recombination initiation and quality control systems.

PloS one - 1 Jan 2018

Ferencziová Veronika, Harami Gábor M, Németh Julianna B, Vellai Tibor, Kovács Mihály

Abstract excerpt

Homologous recombination (HR) is crucial for the error-free repair of DNA double-strand breaks (DSBs) and the restart of stalled replication. However, imprecise HR can lead to genome instability, highlighting the importance of HR quality control. After DSB formation, HR proceeds via DNA end resection and recombinase loading, whereas helicase-catalyzed disruption of a subset of subsequently formed DNA invasions is...

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Identifiers

PMID: 29470542
DOI: 10.1371/journal.pone.0192483
PMCID: PMC5823372

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Source receipt: pubmed, retrieved 7 Sept 2026.

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