Article

NADPH Oxidase 2 Derived Reactive Oxygen Species Promote CD8 <sup>+</sup> T cell Effector Function

2021-02-25

Abstract excerpt

<h4>ABSTRACT</h4> Oxidants participate in lymphocyte activation and function. We previously demonstrated that eliminating the activity of NADPH oxidase 2 (NOX2) significantly impaired the effectiveness of autoreactive CD8 + cytotoxic T lymphocytes (CTL). However, the molecular mechanisms impacting CTL function remain unknown. Here, we studied the role of NOX2 in both non-obese diabetic (NOD) mouse and human CTL...

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Literature Corpus work: fb864768-e12f-5439-a246-d4bfa236453d
DOI: 10.1101/2021.02.24.432756

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