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Chronic granulomatous disease: lessons in cell biology from monogenic immunodeficiency

1 Jan 2025

Abstract excerpt

Reactive oxygen species (ROS) are produced in immune cells by the phagocyte NADPH oxidase (NOX2) system that carries out coordinated transfer of electrons to molecular oxygen. The importance of the system in host defence and immunoregulation is underlined by chronic granulomatous disease (CGD), a severe monogenic immunodeficiency caused by mutations in genes encoding individual components of NOX2. CGD also leads...

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PMID: 40371966
DOI: 10.1093/cei/uxaf031

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