Paradoxical role of programmed death‐1 ligand 2 in Th2 immune responses <i>in vitro</i> and in a mouse asthma model <i>in vivo</i>

Abstract excerpt

Programmed death-1 ligand 2 (PD-L2) is a ligand for programmed death-1 (PD-1), a receptor that plays an inhibitory role in T cell activation. Since previous studies have shown up-regulation of PD-L2 expression by Th2 cytokines, and asthma is driven by a Th2 response, we hypothesized that PD-L2 might be involved in regulation of the immune response in this disease. We have found that lungs from asthmatic mice had...

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