Article
In adult X-CGD patients, regulatory T cells are expanded while activated T cells display a NOX2-independent ROS increase.
Immunology letters - 1 Apr 2024
Cammarata Ilenia, Pinna Valeria, Pacella Ilenia, Rotella Ivano, Soresina Annarosa, Badolato Raffaele, Plebani Alessandro, Pignata Claudio, Cirillo Emilia, Zicari Anna Maria, Violi Francesco, Carnevale Roberto, Loffredo Lorenzo, Piconese Silvia
Abstract excerpt
The X-linked chronic granulomatous disease (X-CGD), a rare genetic disease characterised by recurrent infections, is caused by mutations of NOX2. Significant proportions of X-CGD patients display signs of immune dysregulation. Regulatory T cells (Tregs) are CD4+T lymphocytes that expand in active inflammation and prevent autoimmune disorders. Here we asked whether X-CGD is associated to Treg dysfunctions in adult...
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