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Article

The role of iNKT cells on the phenotypes of allergic airways in a mouse model.

Pulmonary pharmacology & therapeutics - 1 Aug 2017

Lundblad Lennart K A, Gülec Nazey, Poynter Matthew E, DeVault Victoria L, Dienz Oliver, Boyson Jonathan E, Daphtary Nirav, Aliyeva Minara, Ather Jennifer L, Scheuplein Felix, Schaub Robert

Abstract excerpt

iNKT cells and mast cells have both been implicated in the syndrome of allergic asthma through their activation-induced release of Th2 type cytokines and secretion of histamine and other mediators, respectively, which can promote airways hyperresponsiveness (AHR) to agents such as methacholine. However, a mechanistic link between iNKT cells and mast cell recruitment or activation has never been explored. Our...

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Source

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Identifiers

PMID: 28483562
DOI: 10.1016/j.pupt.2017.05.003
PMCID: PMC5534391

Genes

AHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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