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Article

A phenotype of IGFBP-3 knockout mice revealed by dextran sulfate-induced colitis.

Journal of gastroenterology and hepatology - 1 Jan 2017

Yancu Debbie, Blouin Marie-José, Birman Elena, Florianova Livia, Aleynikova Olga, Zakikhani Mahvash, VanderMeulen Heather, Seidman Ernest, Pollak Michael

Abstract excerpt

BACKGROUND AND AIM: Insulin-like growth factor-1 (IGF-1) bioactivity has been shown to be attenuated by insulin-like growth factor binding protein-3 (IGFBP-3), one of six IGF-binding proteins. While prior work revealed no major phenotype associated with IGFBP-3 knockout mice, we explored the possibility that a phenotype could be revealed under specific conditions of gastrointestinal stress. METHODS: The dextran...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27253188
DOI: 10.1111/jgh.13461

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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