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Article

Insulin-like growth factor-I governs submucosal growth and thickness in the newborn mouse ileum.

Pediatric research - 1 Mar 2004

Herman Andrew C, Carlisle Erica M, Paxton Jessica B, Gordon Phillip V

Abstract excerpt

Spontaneous intestinal perforations in extremely premature infants are associated with glucocorticoid-induced thinning of the ileal bowel wall. We have previously demonstrated that insulin-like growth factor-1 (IGF-1) is abundant within the submucosa of the newborn mouse ileum but is diminished by glucocorticoid exposure, concomitant with bowel wall thinning. These findings prompted us to hypothesize that IGF-I...

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PMID: 14681493
DOI: 10.1203/01.PDR.0000110525.30786.50

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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