Article
Mice harboring a defective epidermal growth factor receptor (waved-2) have an increased susceptibility to acute dextran sulfate-induced colitis.
Scandinavian journal of gastroenterology - 1 Nov 2000
Egger B, Büchler M W, Lakshmanan J, Moore P, Eysselein V E
Abstract excerpt
BACKGROUND: It has been reported that epithelial growth factor (EGF) and transforming growth factor-alpha (TGF-alpha) play an important role in colonic mucosal defense and repair. Waved-2 (wa-2) mice harboring a defect EGF-R and phenotypically similar to TGF-alpha knockout mice provide a novel ap...
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