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Article

Altered phenotype of dextran sulfate sodium colitis in interferon regulatory factor-1 knock-out mice.

Journal of gastroenterology and hepatology - 1 Mar 2005

Mannick Elizabeth E, Cote Rae L, Schurr Jill R, Krowicka Halina S, Sloop Gregory D, Zapata-Velandia Adriana, Correa Hernan, Ruiz Bernardo, Horswell Ronald, Lentz Jennifer J, Byrne Patrick, Gastanaduy M Mariella, Hornick Conrad A, Liu Zhiyun

Abstract excerpt

BACKGROUND AND AIMS: Interferon regulatory factor-1 (IRF-1) is a transcription factor with antiviral, proinflammatory and tumor suppressor properties. We examined the role of IRF-1 in dextran sulfate sodium colitis, a murine model of inflammatory bowel disease, to determine if absence of the gene would protect against colitis. METHODS: C57BL/6J mice with a targeted disruption of IRF-1 and wild-type C57BL/6J...

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Identifiers

PMID: 15740479
DOI: 10.1111/j.1440-1746.2005.03573.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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