Article
NHE3 modulates the severity of colitis in IL-10-deficient mice.
American journal of physiology. Gastrointestinal and liver physiology - 1 Jun 2011
Larmonier C B, Laubitz D, Thurston R D, Bucknam A L, Hill F M, Midura-Kiela M, Ramalingam R, Kiela P R, Ghishan F K
Abstract excerpt
NHE3, the major intestinal Na(+)/H(+) exchanger, was shown to be downregulated and/or inhibited in patients with inflammatory bowel disease (IBD), a phenomenon believed to contribute to inflammation-associated diarrhea. NHE3(-/-) mice spontaneously develop colitis and demonstrate high susceptibility to dextran sulfate-induced mucosal injury. We investigated the effects of NHE3 deficiency on the development of...
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