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Article

Sequence alterations of insulin-like growth factor binding protein 3 in neoplastic and normal gastrointestinal tissues.

Cancer research - 1 Nov 1998

Zou T, Fleisher A S, Kong D, Yin J, Souza R F, Wang S, Smolinski K N, Abraham J M, Meltzer S J

Abstract excerpt

Insulin-like growth factor binding protein 3 (IGFBP-3) is an important regulator of normal and malignant cell growth. It modulates the mitogenic effects of insulin-like growth factors (IGFs) by inhibiting growth through mechanisms both dependent on and independent of IGF binding. IGF-I and IGF-II levels are regulated by binding to the IGF-II receptor, which is inactivated by mutation in human gastrointestinal...

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PMID: 9809981

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