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Article

Evasion of cell senescence in SHH medulloblastoma.

Cell cycle (Georgetown, Tex.) - 17 Aug 2016

Tamayo-Orrego Lukas, Swikert Shannon M, Charron Frédéric

Abstract excerpt

The mechanisms leading to brain tumor formation are poorly understood. Using Ptch1+/- mice as a medulloblastoma model, sequential mutations were found to shape tumor evolution. Initially, medulloblastoma preneoplastic lesions display loss of heterozygosity of the Ptch1 wild-type allele, an event associated with cell senescence in preneoplasia. Subsequently, p53 mutations lead to senescence evasion and progression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27229128
DOI: 10.1080/15384101.2016.1189044
PMCID: PMC4993422

Genes

SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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