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Article

Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched.

Cancer research - 15 Jan 2001

Wetmore C, Eberhart D E, Curran T

Abstract excerpt

Brain malignancies represent the most common solid tumors in children, and they are responsible for significant mortality and morbidity. The molecular basis of the most common malignant pediatric brain tumor, medulloblastoma, is poorly understood. Mutations in several genes including the human ho...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 11212243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11212243-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched.PMID 11212243Read ↗

The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched.Semantic proximity Read ↗

Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice.Semantic proximity Read ↗

Two tumor suppressors, p27Kip1 and patched-1, collaborate to prevent medulloblastoma.Semantic proximity Read ↗

Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma.Semantic proximity Read ↗

Patched2 modulates tumorigenesis in patched1 heterozygous mice.Semantic proximity Read ↗

Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors.Semantic proximity Read ↗

<i>Insulin-like Growth Factor 2</i> Is Required for Progression to Advanced Medulloblastoma in <i>patched1</i> Heterozygous MiceSemantic proximity Read ↗

Unbalanced overexpression of the mutant allele in murine Patched mutants.Semantic proximity Read ↗

Time-point and dosage of gene inactivation determine the tumor spectrum in conditional Ptch knockouts.Semantic proximity Read ↗

Altered neural cell fates and medulloblastoma in mouse patched mutants.Semantic proximity Read ↗

Loss of suppressor-of-fused function promotes tumorigenesis.Semantic proximity Read ↗

A mechanistic model for medulloblastoma induction in mice.Semantic proximity Read ↗

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