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Article

PTEN restrains SHH medulloblastma growth through cell autonomous and nonautonomous mechanisms

2025-08-02

Abstract excerpt

A third of patients with the pediatric cerebellar tumor Medulloblastoma (MB) have mutations that activate Sonic hedgehog (SHH) signaling (SHH-MB subgroup). The contribution of secondary mutations to tumor severity, however is not clear. PTEN mutations are enriched in the SHH-1 subtype that has the lowest survival rate. Widespread heterozygous loss of Pten in two SHH-MB mouse models increases penetrance and excel...

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Identifiers and source

Literature Corpus work
3def626c-e2a9-5458-ba29-38fa7e9423c0
DOI
10.1101/2025.07.31.667996
Open publication

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PTEN restrains SHH medulloblastma growth through cell autonomous and nonautonomous mechanismsDOI 10.1101/2025.07.31.667996
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