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Article

Evasion of Cell Senescence Leads to Medulloblastoma Progression

1 Mar 2016

Abstract excerpt

How brain tumors progress from precancerous lesions to advanced cancers is not well understood. Using Ptch1(+/-) mice to study medulloblastoma progression, we found that Ptch1 loss of heterozygosity (LOH) is an early event that is associated with high levels of cell senescence in preneoplasia. In contrast, advanced tumors have evaded senescence. Remarkably, we discovered that the majority of advanced...

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PMID: 26997276
DOI: 10.1016/j.celrep.2016.02.061

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