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Article

PTEN restrains SHH medulloblastoma growth through cell autonomous and nonautonomous mechanisms.

eLife - 17 Apr 2026

Lao Zhimin, El Nagar Salsabiel, Liang Yinwen, Stephen Daniel, Joyner Alexandra L

Abstract excerpt

A third of patients with the pediatric cerebellar tumor Medulloblastoma (MB) have mutations that activate Sonic hedgehog (SHH) signaling (SHH-MB subgroup). The contribution of secondary mutations to tumor severity, however, is not clear. PTEN mutations are enriched in the SHH-1 subtype that has the lowest survival rate. Widespread heterozygous loss of Pten in two SHH-MB mouse models increases penetrance and...

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Share to Cell Differentiation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hedgehog Proteins

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Source

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Identifiers

PMID: 41995080
DOI: 10.7554/eLife.108190
PMCID: PMC13090030

Genes

SHH
MB
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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