Article
Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: Genetic variants as instruments for circulating levels.
International journal of cancer - 1 Oct 2016
Bonilla Carolina, Lewis Sarah J, Rowlands Mari-Anne, Gaunt Tom R, Davey Smith George, Gunnell David, Palmer Tom, Donovan Jenny L, Hamdy Freddie C, Neal David E, Eeles Rosalind, Easton Doug, Kote-Jarai Zsofia, Al Olama Ali Amin, Benlloch Sara, Muir Kenneth, Giles Graham G, Wiklund Fredrik, Grönberg Henrik, Haiman Christopher A, Schleutker Johanna, Nordestgaard Børge G, Travis Ruth C, Pashayan Nora, Khaw Kay-Tee, Stanford Janet L, Blot William J, Thibodeau Stephen, Maier Christiane, Kibel Adam S, Cybulski Cezary, Cannon-Albright Lisa, Brenner Hermann, Park Jong, Kaneva Radka, Batra Jyotsna, Teixeira Manuel R, Pandha Hardev, Lathrop Mark, Martin Richard M, Holly Jeff M P
Abstract excerpt
Circulating insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are associated with prostate cancer. Using genetic variants as instruments for IGF peptides, we investigated whether these associations are likely to be causal. We identified from the literature 56 single nucleotide polymorphisms (SNPs) in the IGF axis previously associated with biomarker levels (8 from a genome-wide association...
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