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Article

Proteome-wide Mendelian randomization identifies causal plasma proteins in prostate cancer development.

Human genomics - 24 Feb 2025

Wu Jian, Yang Zitong, Ding Jiafeng, Hao Sida, Chen Hong, Jin Ke, Zhang Cheng, Zheng Xiangyi

Abstract excerpt

BACKGROUND: The etiology of prostate cancer remained elusive, whether plasma protein levels are associated with prostate cancer is still unknown. METHODS: We have performed Mendelian randomization analyses to calculate the causal effects of plasma proteins on the risk of prostate cancer in the PRACTICAL consortium dataset using cis-protein quantitative trait loci (cis-pQTL) variants as instrumental variables for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39994764
DOI: 10.1186/s40246-025-00724-x
PMCID: PMC11853923

Genes

SMAD2
EIF4B
HDGF
SERPINA3
TNFRSF6B
CLIC1
GNPNAT1
GSK3A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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