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Article

A Novel Pathway-Based Approach Improves Lung Cancer Risk Prediction Using Germline Genetic Variations.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Aug 2016

Qian David C, Han Younghun, Byun Jinyoung, Shin Hae Ri, Hung Rayjean J, McLaughlin John R, Landi Maria Teresa, Seminara Daniela, Amos Christopher I

Abstract excerpt

BACKGROUND: Although genome-wide association studies (GWAS) have identified many genetic variants that are strongly associated with lung cancer, these variants have low penetrance and serve as poor predictors of lung cancer in individuals. We sought to increase the predictive value of germline variants by considering their cumulative effects in the context of biologic pathways. METHODS: For individuals in the...

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PMID: 27222311
DOI: 10.1158/1055-9965.EPI-15-1318
PMCID: PMC5492390

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