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Article

The Shared Genetic Architectures Between Lung Cancer and Multiple Polygenic Phenotypes in Genome-Wide Association Studies.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2021

Byun Jinyoung, Han Younghun, Ostrom Quinn T, Edelson Jacob, Walsh Kyle M, Pettit Rowland W, Bondy Melissa L, Hung Rayjean J, McKay James D, Amos Christopher I

Abstract excerpt

BACKGROUND: Prior genome-wide association studies have identified numerous lung cancer risk loci and reveal substantial etiologic heterogeneity across histologic subtypes. Analyzing the shared genetic architecture underlying variation in complex traits can elucidate common genetic etiologies across phenotypes. Exploring pairwise genetic correlations between lung cancer and other polygenic traits can reveal the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33771847
DOI: 10.1158/1055-9965.EPI-20-1635
PMCID: PMC9108090

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