Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk.

doi:10.1038/s41467-024-52129-4

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Article

Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk.

Nature communications - 4 Oct 2024

Gorman Bryan R, Ji Sun-Gou, Francis Michael, Sendamarai Anoop K, Shi Yunling, Devineni Poornima, Saxena Uma, Partan Elizabeth, DeVito Andrea K, Byun Jinyoung, Han Younghun, Xiao Xiangjun, Sin Don D, Timens Wim, Moser Jennifer, Muralidhar Sumitra, Ramoni Rachel, Hung Rayjean J, McKay James D, Bossé Yohan, Sun Ryan, Amos Christopher I, Pyarajan Saiju

Abstract excerpt

Lung cancer remains the leading cause of cancer mortality, despite declining smoking rates. Previous lung cancer GWAS have identified numerous loci, but separating the genetic risks of lung cancer and smoking behavioral susceptibility remains challenging. Here, we perform multi-ancestry GWAS meta-analyses of lung cancer using the Million Veteran Program cohort (approximately 95% male cases) and a previous study...

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PMID: 39366959
DOI: 10.1038/s41467-024-52129-4
PMCID: PMC11452618

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