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Development and validation of a lung cancer polygenic risk score incorporating susceptibility variants for risk factors.

International journal of cancer - 1 Mar 2025

Ma Zhimin, Zhu Zhaopeng, Pang Guanlian, Gong Feilong, Gao Jiaxin, Ge Wenjing, Wang Guoqing, Zhu Mingxuan, Gong Linnan, Li Qiao, Ji Chen, Fu Yating, Jin Chen, Ma Hongxia, Ji Yong, Zhu Meng

Abstract excerpt

Incorporating susceptibility genetic variants of risk factors has been reported to enhance the risk prediction of polygenic risk score (PRS). However, it remains unclear whether this approach is effective for lung cancer. Hence, we aimed to construct a meta polygenic risk score (metaPRS) of lung cancer and assess its prediction of lung cancer risk and implication for risk stratification. Here, a total of 2180...

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Genetic Risk Score
Lung Neoplasms
Multifactorial Inheritance
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proportional Hazards Models

Risk Assessment

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PMID: 39378120
DOI: 10.1002/ijc.35210

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