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Article

A trans-omics gene-smoking interaction study of lung cancer based on consortium data.

American journal of respiratory and critical care medicine - 1 Jun 2026

Xie Ning, Xu Xiaowen, Wang Yanru, Wang Aoxuan, Wang Xiang, Wang Xuan, Zhao Mengsheng, Zhou Jiacheng, Wei Yongyue, Esteller Manel, Hu Zhibin, Shen Hongbing, Hung Rayjean J, Amos Christopher I, Li Yi, Christiani David C, Chen Feng, Zhao Yang, Zhang Ruyang

Abstract excerpt

RATIONALE: Genetically predicted molecular traits provide a cost-effective approach for identifying biomarkers and uncovering underlying biological mechanisms. We extended this framework to investigate gene-smoking interactions in lung cancer susceptibility. OBJECTIVES: To identify trans-omics gene-smoking interactions affecting lung cancer risk and to assess how biomarkers modify effect of smoking. METHODS: We...

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PMID: 41738161
DOI: 10.1093/ajrccm/aamaf097
PMCID: PMC13365843

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