Genome-wide meta-analysis across East Asian and European populations provides insights into the molecular basis of lung cancer.

doi:10.1186/s13073-026-01666-2

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Genome-wide meta-analysis across East Asian and European populations provides insights into the molecular basis of lung cancer.

Genome medicine - 18 May 2026

Zhu Meng, Zhang Caochen, Han Yuting, Jin Chen, Miao Sunan, Zhang Jing, Gong Linnan, Mou Yuanlin, Ji Chen, Fu Yating, Zhang Erbao, Yu Canqing, Sun Dianjianyi, Jiang Yue, Chen Jiaping, Yang Ling, Chen Yiping, Du Huaidong, Walters Robin, Millwood Iona, Dai Juncheng, Chen Zhengming, Hu Zhibin, Lv Jun, Jin Guangfu, Amos Christopher I, Shen Hongbing, Li Liming, Ma Hongxia

Abstract excerpt

BACKGROUND: The genetic architecture of lung cancer (LC) varies substantially across populations. However, the limited ancestral diversity of existing discovery cohorts hampers comprehensive characterization of ancestry-specific risk mechanisms and limits the transferability of polygenic risk scores (PRSs) across populations. In addition, the interplay between germline variants and somatic mutations in LC remains...

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PMID: 42152146
DOI: 10.1186/s13073-026-01666-2
PMCID: PMC13348699

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CKB
MPHOSPH6

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