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Development and evaluation of a polygenic risk score for lung cancer in never-smoking women: A large-scale prospective Chinese cohort study.

International journal of cancer - 1 Mar 2024

Wei Xiaoxia, Sun Dianjianyi, Gao Jiaxin, Zhang Jing, Zhu Meng, Yu Canqing, Ma Zhimin, Fu Yating, Ji Chen, Pei Pei, Yang Ling, Millwood Iona Y, Walters Robin G, Chen Yiping, Du Huaidong, Jin Guangfu, Chen Zhengming, Hu Zhibin, Li Liming, Shen Hongbing, Lv Jun, Ma Hongxia

Abstract excerpt

The proportion of lung cancer in never smokers is rising, especially among Asian women, but there is no effective early detection tool. Here, we developed a polygenic risk score (PRS), which may help to identify the population with higher risk of lung cancer in never-smoking women. We first performed a large GWAS meta-analysis (8595 cases and 8275 controls) to systematically identify the susceptibility loci for...

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PMID: 37846649
DOI: 10.1002/ijc.34765

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