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Epstein-Barr virus nuclear protein EBNA3C directly induces expression of AID and somatic mutations in B cells

23 May 2016

Abstract excerpt

Activation-induced cytidine deaminase (AID), the enzyme responsible for induction of sequence variation in immunoglobulins (Igs) during the process of somatic hypermutation (SHM) and also Ig class switching, can have a potent mutator phenotype in the development of lymphoma. Using various Epstein-Barr virus (EBV) recombinants, we provide definitive evidence that the viral nuclear protein EBNA3C is essential in...

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PMID: 27217538
DOI: 10.1084/jem.20160120

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