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Article

Epstein-Barr virus nuclear antigen 2 inhibits AID expression during EBV-driven B-cell growth

2 Aug 2006

Abstract excerpt

Somatic hypermutation and class-switch recombination in germinal centers critically depend on activation-induced cytidine deaminase (AID). Deregulation of AID may lead to the aberrant activation or persistence of both genetic processes, thus contributing to the pathogenesis of B-cell lymphomas by mistargeted mutagenesis or recombination. The Epstein-Barr virus (EBV) establishes an asymptomatic latent infection in...

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PMID: 16882707
DOI: 10.1182/blood-2006-05-021303

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