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EBV epigenetically suppresses the B cell-to-plasma cell differentiation pathway while establishing long-term latency

3 Aug 2017

Abstract excerpt

Mature human B cells infected by Epstein-Barr virus (EBV) become activated, grow, and proliferate. If the cells are infected ex vivo, they are transformed into continuously proliferating lymphoblastoid cell lines (LCLs) that carry EBV DNA as extra-chromosomal episomes, express 9 latency-associated EBV proteins, and phenotypically resemble antigen-activated B-blasts. In vivo similar B-blasts can differentiate to...

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PMID: 28771465
DOI: 10.1371/journal.pbio.2001992

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