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Article

High expression of activation-induced cytidine deaminase (AID) and splice variants is a distinctive feature of poor-prognosis chronic lymphocytic leukemia.

Blood - 15 Jun 2003

McCarthy Helen, Wierda William G, Barron Lynn L, Cromwell Candy C, Wang Jing, Coombes Kevin R, Rangel Roberto, Elenitoba-Johnson Kojo S J, Keating Michael J, Abruzzo Lynne V

Abstract excerpt

In chronic lymphocytic leukemia (CLL), analysis of immunoglobulin heavy chain variable regions for somatic hypermutation identifies 2 prognostic subsets, mutated and unmutated. Investigators have postulated that unmutated and mutated CLL arises from malignant transformation of pre- and post-germinal center (GC) B cells, respectively. Alternatively, unmutated cases may arise from B cells stimulated by...

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Identifiers

PMID: 12586616
DOI: 10.1182/blood-2002-09-2906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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High expression of activation-induced cytidine deaminase (AID) and splice variants is a distinctive feature of poor-prognosis chronic lymphocytic leukemia.PMID 12586616Read ↗

Activation-induced cytidine deaminase in chronic lymphocytic leukemia B cells: expression as multiple forms in a dynamic, variably sized fraction of the cloneSemantic proximity Read ↗

AID in Chronic Lymphocytic Leukemia: Induction and Action During Disease ProgressionSemantic proximity Read ↗

IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions.Semantic proximity Read ↗

Alternative splicing regulates activation-induced cytidine deaminase (AID): implications for suppression of AID mutagenic activity in normal and malignant B cellsSemantic proximity Read ↗

Activation-induced Cytidine Deaminase in B Cell Immunity and CancersSemantic proximity Read ↗

High expression of activation-induced cytidine deaminase (AID) mRNA is associated with unmutated IGVH gene status and unfavourable cytogenetic aberrations in patients with chronic lymphocytic leukaemiaSemantic proximity Read ↗

Expression of the AID protein in normal and neoplastic B cells.Semantic proximity Read ↗

AID Biology: A pathological and clinical perspectiveSemantic proximity Read ↗

Biological function of activation-induced cytidine deaminase (AID)Semantic proximity Read ↗

AID protein expression in chronic lymphocytic leukemia/small lymphocytic lymphoma is associated with poor prognosis and complex genetic alterations.Semantic proximity Read ↗

High expression of AID and active class switch recombination might account for a more aggressive disease in unmutated CLL patients: link with an activated microenvironment in CLL disease.Semantic proximity Read ↗

Whole-genome sequencing reveals activation-induced cytidine deaminase signatures during indolent chronic lymphocytic leukaemia evolution.Semantic proximity Read ↗

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