Article
Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model.
Neuron - 1 Jun 2016
Schoch Kathleen M, DeVos Sarah L, Miller Rebecca L, Chun Seung J, Norrbom Michaela, Wozniak David F, Dawson Hana N, Bennett C Frank, Rigo Frank, Miller Timothy M
Abstract excerpt
Pathological evidence for selective four-repeat (4R) tau deposition in certain dementias and exon 10-positioned MAPT mutations together suggest a 4R-specific role in causing disease. However, direct assessments of 4R toxicity have not yet been accomplished in vivo. Increasing 4R-tau expression without change to total tau in human tau-expressing mice induced more severe seizures and nesting behavior abnormality,...
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