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Article

Tau isoform regulation is region‐ and cell‐specific in mouse brain

29 Oct 2008

Abstract excerpt

Tau is a microtubule-associated protein implicated in neurodegenerative tauopathies. Alternative splicing of the tau gene (MAPT) generates six tau isoforms, distinguishable by the exclusion or inclusion of a repeat region of exon 10, which are referred to as 3-repeat (3R) and 4-repeat (4R) tau, respectively. We developed transgenic mouse models that express the entire human MAPT gene in the presence and absence...

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PMID: 18925637
DOI: 10.1002/cne.21867

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