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Article

The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition.

Molecular neurodegeneration - 4 Oct 2017

Eskandari-Sedighi Ghazaleh, Daude Nathalie, Gapeshina Hristina, Sanders David W, Kamali-Jamil Razieh, Yang Jing, Shi Beipei, Wille Holger, Ghetti Bernardino, Diamond Marc I, Janus Christopher, Westaway David

Abstract excerpt

BACKGROUND: MAPT mutations cause neurodegenerative diseases such as frontotemporal dementia but, strikingly, patients with the same mutation may have different clinical phenotypes. METHODS: Given heterogeneities observed in a transgenic (Tg) mouse line expressing low levels of human (2 N, 4R) P301L Tau, we backcrossed founder stocks of mice to C57BL/6Tac, 129/SvEvTac and FVB/NJ inbred backgrounds to discern the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28978354
DOI: 10.1186/s13024-017-0215-7
PMCID: PMC5628424

Genes

MAPT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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