Lack of exon 10 in the murine tau gene results in mild sensorimotor defects with aging

Abstract excerpt

BACKGROUND: Complex species-specific, developmental- and tissue-dependent mechanisms regulate alternative splicing of tau, thereby diversifying tau protein synthesis. The functional role of alternative splicing of tau e.g. exon 10 has never been examined in vivo, although genetic studies suggest that it is important to neurodegenerative disease. RESULTS: Gene-targeting was used to delete exon 10 in murine tau on...

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