Article

Neutrophils impair B cell differentiation via mitochondrial and lipid metabolism in lupus

2026-02-06

Abstract excerpt

<h4>Summary</h4> Systemic lupus erythematosus (SLE) is characterised by aberrant neutrophil activation and pathogenic B-cell responses that drive organ damage, particularly in lupus nephritis (LN). Here, we identify neutrophil-derived mitochondrial DNA (mtDNA) as a metabolic driver of B-cell dysregulation in LN. Using single-cell transcriptomics of human blood and kidney tissue together with functional co-culture...

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Literature Corpus work: 497fc329-4ab4-5e72-af90-cbc799293d4f
DOI: 10.64898/2026.02.03.703615

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