Article
BRD9 depletion-mediated ALOX5 upregulation via chromatin dysregulation induces ferroptosis in SF3B1-mutant hematopoiesis.
International journal of hematology - 1 Mar 2026
Saika Wataru, Yamazaki Hiromi, Tanaka Shota, Lin Min, Oshima Seigi, Gao Ziyu, Nomura Masaki, Zang Weijia, Koike Yui, Xiao Muran, Ito Hiromi, Matsumoto Naomi, Yamasaki Takaya, Nishimura Koutarou, Murata Makoto, Inoue Daichi
Abstract excerpt
SF3B1 mutations are among the most common splicing factor mutations in myeloid malignancies, yet the mechanisms linking aberrant splicing to metabolic phenotypes remain incompletely understood. We previously demonstrated that SF3B1 mutations cause nonsense-mediated decay of BRD9, a core component of the non-canonical BAF chromatin remodeling complex. Here, we investigated how the SF3B1-BRD9 pathway contributes to...
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