Aspartate transaminases are required for blood development

Abstract excerpt

Red blood cells (RBCs) have a limited lifespan of approximately 120 days. This necessitates continuous RBC production, resulting in ∼200 billion new RBCs made per day to maintain oxygen delivery. Despite this enormous biosynthetic demand, the metabolic pathways supporting erythropoiesis are poorly understood. We profiled metabolites across four independent models of elevated erythropoiesis and a consistent increas...

Topics

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• Adult Stem Cells
• Anemia
• Cellular Senescence
• Down syndrome and intellectual disability research
• Electron Transport
• Electron Transport Complex III
• Glutarates
• NAD

Identifiers and source

Literature Corpus work

29486122-0d46-5d84-b3e5-7d2c0c532f01

DOI

10.1101/2025.09.16.675844