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Article

Complete Spectrum of CRISPR/Cas9-induced Mutations on HBV cccDNA.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Aug 2016

Seeger Christoph, Sohn Ji A

Abstract excerpt

Hepatitis B virus (HBV) causes chronic infections that cannot yet be cured. The virus persists in infected hepatocytes, because covalently closed circular DNA (cccDNA), the template for the transcription of viral RNAs, is stable in nondividing cells. Antiviral therapies with nucleoside analogues inhibit HBV DNA synthesis in capsids in the cytoplasm of infected hepatocytes, but do not destroy nuclear cccDNA....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27203444
DOI: 10.1038/mt.2016.94
PMCID: PMC5088770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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